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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically described as a focus on the practical aspects of study design, including the recruitment process and consent, adhering and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from different geographic areas. This type of heterogeneity which is vital for a pragmatic trial to be reliable and reduce bias in results is also essential. Too much heterogeneity, however, 프라그마틱 공식홈페이지 can cause problems with the design of the trial.

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The aim of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. Usually, they are commissioned by policymakers and practitioners to help guide their decisions. They can also be a great method of determining the causal relationship between an intervention and its outcomes. However, they should not, be used to replace the need for explanation studies.

The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and 프라그마틱 슬롯 하는법 practice. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool sought to define the elements of a pragmatic trial, including recruitment, design and delivery of the intervention, as well as follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatics. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.